Proud to share our latest paper! In this study, we explored how microenvironmental and culture conditions shape the fitness and plasticity of human islets.
Combining ECM enrichment with dynamic free-fall culture enhanced islet resilience, preserved glucose responsiveness, and promoted better stress adaptation.
These insights contribute to optimizing ex vivo maintenance of rare human tissues, such as pancreatic islets, with potential impact on cell-based therapies for type 1 diabetes.
Thank you to Isaura Beatriz Borges Silva, Marluce Mantovani, Minh Luu Danh Anh, Alan Ray Gorter, theo borghuis, Naschla Gasaly, Mari Cleide Sogayar, and Paul de Vos for the great team effort in bringing it to life!! 💪