Matrix Organoid Lab

trombetta-lima's group

Navigating the Cellular Cosmos: Exploring the Dynamic Landscape of Tissue Microenvironment!

About Us

Our research endeavours are driven by a curiosity to dissect how the tissue microenvironments influences the aging process, specifically how age-related alterations in these microenvironments influence susceptibility to various diseases.

THE AGING PROCESS

Employing state-of-the-art methodologies such as organoid models and gene editing techniques, we explore aging in vitro through two distinct approaches:

Inside-Out: By manipulating cellular compartments via gene editing, we induce accelerated aging phenotypes. This approach allows us to unravel the intricate molecular mechanisms underlying age-related modifications within cells.

Outside-In: Here, our focus shifts to the tissue microenvironment itself. Through targeted modifications, we mimic accelerated aging conditions in the microenvironment, shedding light on how external factors impact tissue aging and disease susceptibility.

Beyond our core focus on tissue microenvironments, we are also deeply intrigued by theintricate communication networks between different organs and their role in age-related diseases. By delving into these complex interactions, we aim to unearth novel therapeutic targets and interventions to combat age-related diseases.

Join us on this captivating journey as we navigate the fascinating realm of tissue microenvironments, aging, and disease susceptibility, striving to make impactful contributions to the field of biomedical research.

Our Models

Using 3D models to uncover the mechanisms of aging

brain organoid

Brain

Liver organoid

Liver

Pancreas

heart organoid

Heart

Blood-brain-barrier

glioblastoma organoid

Glioblastoma

Human in vitro models

We are committed to the 3 R’s principle – Replace, Reduce, Refine – in our research endeavors, ensuring ethical and humane practices while advancing scientific discovery.

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