Employing state-of-the-art methodologies such as organoid models and gene editing techniques, we explore aging in vitro through two distinct approaches:

Inside-Out: By manipulating cellular compartments via gene editing, we induce accelerated aging phenotypes. This approach allows us to unravel the intricate molecular mechanisms underlying age-related modifications within cells.

Outside-In: Here, our focus shifts to the tissue microenvironment itself. Through targeted modifications, we mimic accelerated aging conditions in the microenvironment, shedding light on how external factors impact tissue aging and disease susceptibility.

Beyond our core focus on tissue microenvironments, we are also deeply intrigued by theintricate communication networks between different organs and their role in age-related diseases. By delving into these complex interactions, we aim to unearth novel therapeutic targets and interventions to combat age-related diseases.

Join us on this captivating journey as we navigate the fascinating realm of tissue microenvironments, aging, and disease susceptibility, striving to make impactful contributions to the field of biomedical research.